Susceptibility Search Results

News: This Genetic Defect Could Be Why Typhoid Mary Never Got Typhoid Fever

Whether or not a microbe is successful at establishing an infection depends both on the microbe and the host. Scientists from Duke found that a single DNA change can allow Salmonella typhi, the bacteria that causes typhoid fever, to invade cells. That single genetic variation increased the amount of cholesterol on cell membranes that Salmonella and other bacteria use as a docking station to attach to a cell to invade it. They also found that common cholesterol-lowering drugs protected zebrafi...

News: Starve E Coli of Copper to Cure Aggressive UTIs

Urinary tract infections (UTIs) drive over eight million people to seek medical attention every year. Almost all — as many as 90% — of those infections are caused by Escherichia coli. Copper can kill bacteria, but E. coli has found a way to capture the copper, preventing its antibacterial action. Now, researchers have found that, in a cruel irony, the bacteria use the copper it grabs as a nutrient to feed its growth.

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